There is a contrary relationship between the growth of fungal hyphae and the accumulation of taxol in the mycelium.
The effect of elicitor and other precursors for the synthesis of taxol on both the growth and activity of dehydrogenase of yew cells was studied.
The effects of phenylalanine, sucrose and mannitol on the cell growth and the production of taxol, baccatin III and 10deacetylbaccatin III in the suspension cells of Taxus media were studied.
Cell livability of group taxol is lower than group accelerated radiation.
Effects of sugar content, carbon source, nitrogen source and precursor feeding on taxol production of endophytic fungus in liquid fermentation were studied .
The regulation of taxol biosynthesis is one of the key techniques to produce taxol by cell culture.
It is also possible that it could be used as an addition to taxol and other similar drugs to increase effective killing of tumor cells without increased toxicity.
Cell growth is obviously suppressed in the human laryngeal squamous cell carcinoma Hep 2 cell lines after given 1×10 -8 mol/L taxol combined 2 Gy X rays generated by accelerator. Taxol acts as a radiation sensitizer.
And the supply of the drug from nature resources, yew trees and African fern pine( Podocarpus gracilior Pilger), which are grow very slowly and contain only a small amount of taxol, is very limited.
Those results provided guidance for further research on mechanism of elicitation and regulation of taxol biosynthesis in Taxus cells.
